Тhe article "the Use of cluster analysis method to assess the differentiation of the regions of the Republic of Kazakhstan in terms of social and economic development" analyzes the socio-economic development of the regions of Kazakhstan using the cluster analysis method. Comprehensive socio - economic assessment of the regions of the Republic showed significant differences in the state of labor and socio-economic potential. The proposed differentiation of areas justified the choice of the necessary forms and methods of effective regulation of economic and social processes.